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Bilirubin oxidation was enhanced in the diseased skin of patients with AD and levels of the oxidized metabolite biopyrrin detected in urine correlated with the severity of AD (24)

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Of note, genetic associations between these loci and metabolite ratios were the strongest at the time point that showed insignificant metabolitemetabolite interactions on the HRSD 17 score

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Journal of Traditional and Complementary Medicine, 5 (1), 1520