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In ICU patients : Where immediate and direct nutrition to the body is required

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Under physiological conditions, the intestinal barrier must ensure the right balance between the selective permeability of dietary nutrients from the intestinal lumen to the systemic circulation and internal environment, and the protection of the body from the penetration of pathogens and harmful components of the external environment

However, risk factors include: a family history of pernicious anemia a family history of other autoimmune disorders, such as vitiligo and Addisons disease being female older age Pernicious anemia is a common cause of vitamin B12 deficiency

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