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Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

Consistently, NAC and cysteine have also been shown to enhance Cu 2+ reduction and copper-induced proteotoxic stress, 168 suggesting that thiol-rich reducing environments can, under specific conditions, contribute to cytotoxicity

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