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For antibody staining, antigen retrieval was performed on the slides by incubating them in a steamer for 40 min in citrate buffer (Vector Labs, Cat# H-3300-250)

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Moreover, the quantitative analysis of SOD activity illustrated that the SOD activities of BP@CeO x were 5.30-fold and 6.15-fold higher than pure BP and CeO x in the acidic/ROS-enriched environment after co-incubation for 28 days, indicating that BP@CeO x exhibited a higher SOD scavenging ability in the mimic degenerative NP environment for a long time (Fig.3k and Supplementary Fig

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