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Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, Broedl UC, Inzucchi SE

Enzymes that depend on VIC as a cofactor fall into two main categories: iron-dependent or 2-oxoglutarate-dependent dioxygenases

4 DPN affects approximately 50% of individuals with diabetes during their lifetime and can be classified based on the type of nerve fibers affected

Zimmermann 2005)

The protein content was calculated from the nitrogen content determined by the Kjeldahl method using a nitrogen-to-protein conversion factor (k p ) of 4.78

These enzymes are critical gatekeepers in the citric acid cycle (Krebs cycle), the primary metabolic pathway that oxidizes carbohydrates, fats, and proteins to produce ATP