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Throughout the study, it was found that sublingual GSH and NAC led to significant improvements in glutathione levels, while oral GSH did not due to its low bioavailability ( 6 )

If your goal is to reduce the appearance of dark spots and even out your skin tone, you might consider pairing glutathione with other targeted supplements

The compound progressed through Phase 2 trials under ConjuChem in the mid-2000s for indications including HIV-associated lipodystrophy, but did not advance to a marketed therapeutic