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The review also noted that several interventions, such as caloric restriction, exercise, and supplementation to increase glutathione, improve longevity

Li R, Li Y, Song Z, Gu Y, Jiao X, Wan C, et al

James also connected autism, depression and Alzheimers

In contrast, males exhibited broader transcriptional disruption of excitatory and myelination-related pathways, in line with prior work showing that prenatal adversity and cannabinoids impair oligodendrocyte maturation, axonal integrity, and glutamatergic signaling within reward-related regions [73, 74, 75]