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The intestinal absorption of carnitine, as well as its renal reabsorption, is primarily mediated by the plasma membrane organic cation transporter novel 2 (OCTN2 SLC22A5) that, among the carnitine-handling transporters, shows the highest affinity toward carnitine

Moreover, it plays an important role in the development of many metabolic diseases, such as hypertension, diabetes, polycystic ovary syndrome (8), and osteoarthritis (9)

These results suggest that chronic GPLC use, even at higher doses, does not meaningfully alter muscle carnitine storage or improve aerobic or anaerobic performance in recreationally active individuals (44)

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Pediatr Res 2011

Stanbrough, M