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Akt activation plays a pivotal role in mitigating ischemia-reperfusion injury by suppressing apoptotic pathways, enhancing cell survival signals, and promoting Nrf2 nuclear translocation [23]

Although HIF-2 has biochemical characteristics similar to those of HIF-1, the metabolic role of HIF-2 in a low-oxygen environment is relatively unknown 68

Acknowledgments MD would like to thank James Cook University for a PhD scholarship

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In addition, patients receiving rintatolimod also demonstrated reductions in concomitant medication use and significant enhancements in Karnofsky Performance Scores and activities of daily living (ADL) compared to those on placebo [106]