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When the concentrations detected by three-phase HF-LPME were used to fit the correlations between the concentration and immobilization ratio, the correlation significantly improved compared to that using the nominal concentration, independent of the solution pH, suggesting that three-phase HF-LPME is a useful tool for estimating the toxicity of sulfadiazine and perhaps other weakly acidic organic compounds, independent of the solution pH

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many people believe that these natural remedies have a lower risk of adverse side effects than prescription medications