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In females, the increase in AUClast and Cmax was greater than dose proportional from 1.25 mg/kg to 1.5 mg/kg and there was minimal increase in exposure from 1.5 mg/kg to 1.75 mg/kg on both evaluation days

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Another UPR branch is activated by IRE1, which following their dimerization and autophosphorylation 70 , generates a functional spliced XBP1 ( XBP1s ) 71 that as a transcription factor regulates the expression of numerous genes maintaining ER and metabolic homeostasis 7278 (Figure 2)