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The compound does not exist as a stable free molecule in the body

Convection-enhanced drug delivery for glioblastoma: a review

However, TGF- has a disruptive effect on glomerular filtration, leading to glomerular damage in the early stage of DN and directly increasing the permeability of the glomerulus to albumin (Palb), which is associated with a decrease in 20-HETE formation (Sharma et al., 2000

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Mechanistically, AS-IV may improve lipid metabolism in obese mice by increasing leptin sensitivity and regulating thermogenesis-related networks (Wu et al., 2016)