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Similar to amyloid pathology models, positive correlations between depressive-like behavior and tau pathology in the hippocampus and cortex and associated neuroinflammation have been observed in Tau pathology models such as 6xTg and THY-Tau22 (Schindowski et al., 2006

[DOI] [PubMed] [Google Scholar] 60.Yang J., Kurnia P., Henning S.M., Lee R., Huang J., Garcia M.C., Surampudi V., Heber D., Li Z

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Exp Toxicol Pathol 44:169181 Davies KJ (1995) Oxidative stress: the paradox of aerobic life

Three P450 genetic polymorphisms have been particularly well characterized, affording some insight into possible underlying molecular mechanisms, and are clinically noteworthy, as they require therapeutic dosage adjustment