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We proposed these changes to be effective beginning with the CY 2024 performance period/2026 MIPS payment year for the data submission period in CY 2025

A clear example is provided by FGFR-driven lung cancer cells exposed to the tyrosine kinase inhibitor ponatinib: the inhibitor is selectively taken up by LDs in a process termed LD-mediated scavenging, and increased drug LD load correlates with drug resistance, whereas pharmacological inhibition of LD biogenesis (e.g., by Triacsin C) restores sensitivity 143

10.1177/0300060519883752 190 ZouK.SunP.HuangH.ZhuoH.QieR.XieY.et al (2022)

At low doses (125 g/kg), metformin activates AMPK, enhancing endothelial nitric oxide synthase (eNOS) activity, improving vascular function, and reducing myocardial injury (Zhou et al., 2001)

Klotho expression was dramatically reduced in animal models of CP-induced POF compared to the control group (Liu et al

During this period, the patent dance commences within 20 days of aBLA acceptance