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Upon ligand binding, the nanoparticle-receptor complex is internalized via clathrin-coated vesicles to be transported across the BBB and subsequently released by exocytosis into the brain parenchyma 119,120

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Alongside, resistant cells enhance serine metabolism to boost glutathione synthesis, reinforcing antioxidant defenses

Secondary metrics included average inflammatory and non-inflammatory lesion counts, as well as scores on the standardized Dermatology Life Quality Index (DLQI)

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