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de Freitas Carvalho MM, Lage NN, de Souza Paulino AH et al (2019) Effects of aai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD

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311 Under typical oxygen conditions, Nt-Cys2 undergoes oxidation catalyzed by either plant cysteine oxidase 1 (PCO1) or PCO2, followed by arginylation by ATE1, resulting in the formation of Nt-Arg-CysO 2 (H) (RC O2 )

This supports the hypothesis that decreased wound contraction by myofibroblasts could contribute to delayed wound healing in smokers

Specifically, copper catalyzes the Fenton reaction, generating reactive oxygen species (ROS) that directly cause oxidative damage to critical biomacromolecules such as lipids, proteins, and DNA (Sebk-Nagy et al., 2023