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Moreover, polyQ-expanded ataxin-3 was found to exacerbate TP53-dependent neurotoxicity, while maintaining strong binding and deubiquitination activity 103

Second, in SLC30A10-deficient patients, the severity of liver injury is correlated with hepatic Mn accumulation, yet whether this pathology is linked to the MnCOPII-mediated retention of lipoproteins in hepatocytes is currently unknown

All stains were performed according to manufacturing protocols

Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis