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Concurrently, oxidative stress-related enzymes exhibited distinct expression patterns

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Zang et al

Plasma concentrations of insulin and leptin were measured using a custom developed Mesoscale (MSD) multiplex assay, which is a multi-array assay with electrochemiluminescence readout

The metabolically stabilized 6-AH family member, D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , had a t| /2 in blood of 80 min compared to the parent compound Norleual (Nle-Tyr-Leu-T-(CH 2 -N) 3 -His-Pro-Phe, SEQ ID NO: 1), which had a tj 2 in blood of Cm ax concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (ti 2 ), volume of distribution (Vd), and clearance (CL)