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However, dysfunction of IDO2 in combination with tryptophan inhibition of IDO1 results in increased cytosolic tryptophan, reduced kynurenine production and downstream metabolites including quinolinate and NAD +

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Estrogen treatment rescues ovariectomy-induced hepatic inflammation as well as systemic inflammation Loss of estrogen has been linked to activation of inflammatory pathways, specifically in postmenopausal women where this is prominent with increased emergence of liver disorders and cardiovascular diseases 66,67,68,69,70