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However, mRNA levels of neurotrophic factors, including IGF-I, GDNF, BDNF, and anti-inflammatory factors were decreased in the spinal cords of SOD1 G93A /RAG2 / and SOD1 G93A /CD4 / mice, as were the levels of CX3CR1 and several glutamate receptors

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Intestinal bacteria produce secretory bacterial enzymes that facilitate the breakdown and digestion of polysaccharides in food, enhancing the absorption of food nutrients ( Alterations in intestinal flora can impact the integrity of the intestinal mucosal barrier including the structure of intestinal mucous layer, antimicrobial peptides and tight junction proteins, leading to increased intestinal permeability

Malassezia glabrata's hydrophobic components cause human epidermal keratinocytes to produce inflammatory proteins, which in turn cause peripheral blood Th1-biased differentiation of Th cell subsets