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2.4 Unhealthy lifestyle and oxidation homeostasis in atherosclerosis Oxidative stress caused by smoking is generally considered a significant independent risk factor for atherosclerosis (Niemann et al., 2017)

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The experiment was performed in triplicate at a minimum

Mol Imaging Biol (2016) 18(1):1823

NAD + is rapidly converted to NADH by the malate shuttle and mitochondrial transhydrogenase to establish redox balance and power oxidative phosphorylation

Mechanistically, LBNP-PC@M restores angiogenesis by activating the Nrf2/HO-1 axis, downregulating antiangiogenic factors, and stabilizing endothelial tight junctions