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The uptake of PA by cells often requires the mediation of fatty acid transport protein CD36 [54], and it can also be encapsulated within extracellular vesicles or particles (EVPs) to enter and exit cells via endocytosis and exocytosis [55]

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In addition, low-dose KET has been beneficial on large numbers of patients suffering from oncological and non-oncological pain (Cohen et al., 2018

These critical mediators modulate immune function and inflammatory responses through genomic and non-genomic regulation of intracellular metabolic pathways, including glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation

A medication used to treat seizures is well known to cause carnitine deficiency

After a pre-processing step (peak integration and concentration determination from calibration curves) with Multiquant software (AB Sciex, Darmstadt, Germany), data were uploaded into Biocrates MetIDQ software (included in the kit)