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GI disorders like celiac disease and inflammatory bowel disease (IBD) reduce the bodys ability to absorb and maintain healthy B12 stores

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M.de la ChapelleA.et al (2004)

The more depleted your body is, the more time and consistent supplementation it will take to feel the full effects

When anemia is present, i.e., low levels of the oxygen carrier hemoglobin, it results in impaired oxygen delivery, which affects not only cognitive function but also physical performance and perception of fatigue and tiredness