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Metabolomics data was analyzed using the web-based platform Metaboanalyst 5.0 ( Univariate analysis of peak intensity values was performed by volcano plot analysis wherein p- values were determined with a two-sided Wilcoxon rank-sum test and then adjusted for multiple testing by FDR correction using an adjusted p -value ( q ) threshold of q = 0.05

Thymosin 4 and its derivatives, including TB-500, are prohibited at all times under the WADA growth-factor section, and BPC-157 is prohibited as a non-approved substance [13]