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Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events

Our study has indicated that ERK links SIRT2 and the NAD + treatment-produced changes of the GSH/GSSG ratio, the GCL levels and the Nrf2 activity in our experimental model: first, both SIRT2 siRNA and AGK2 can prevent the NAD + -induced increase in ERK phosphorylation, indicating that SIRT2 mediates the NAD + -induced ERK phosphorylation

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2 Flexibility decreases the intensity of OCD

Deschwanden, A

(MOV 26066 kb) Purinergic receptor and connexin hemichannel signaling mediate the innate immune response to compression injury (download MOV Part 1: Representative time lapses were captured in a CX3CR1 mice pretreated transcranially with P2Y12, P2Y6, P2X4, or P2X7 receptor antagonists and imaged beginning 5 min post-compression injury