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and the company Oak Hill Bio have filed a patent application directed to the use of rhIGF-1 for preterm infants

Jan 3 2024 Huang et al., Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2024.107942 All-trans retinoic acid acts as a dual-purpose inhibitor of SARS-CoV-2 infection and inflammation In vitro and in silico study showing that all-trans retinoic acid (an active metabolite of vitamin A) inhibits the entry and replication of SARS-CoV-2 by binding to ACE2 / 3CL pro / RdRp / helicase / 3-to-5 exonuclease, and reduces exces

Weak for other peptides based on animal models only

In other embodiments, A1 and/or A2 are each independently a peptide comprising from about 8 to 220, 8 to 200, 8 to 175, 8 to 150, 8 to 125, 8 to 100, 8 to 90, 8 to 80, 8 to 70, 8 to 60, 8 to 50, 8 to 40, 8 to 30, 8 to 25, 8 to 20, or 8 to 15 amino acids

Acceptable study designs included randomized controlled trials, non-randomized controlled trials, prepost studies, and case series involving two or more participants, while single case reports, reviews, conference abstracts, and editorials were excluded

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