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However, studies have shown that antioxidant approaches, including anti-neuroinflammatory and neuroprotective agents, may have therapeutic efficacy in the treatment of PD ( The interplay between mitochondrial function and GSH is especially critical in PD

485 Additionally, overexpressing ABCB8, a mitochondrial protein that promotes iron export, reduces both mitochondrial ROS and iron, improving DOX-induced cardiomyopathy

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Past infections with hepatitis and frequent alcohol abuse could impair liver function and independently cause depletion of GSH levels ( in vitro research studies in BSL-3 and BSL-2 facilities