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It also reduced the extent of ALI, as evidenced by reductions in LW changes, exhaled NO, PCBAL and lung pathology

J Biol Chem 279(40):4180141806

Interestingly, the nature of NO as an endothelial-derived relaxing factor was initially not universally accepted because of these reactions: the reasoning of many researchers in this field was that the presence of a highly efficient scavenger in direct vicinity of the main source of NO would produce a concentration gradient leading to diffusion of NO into the blood stream (instead of into the smooth muscle) and thereby prevent vasodilatory function

However, there is lack of in vivo evidence demonstrating that amino acid supplementation may effectively reduce central fatigue

Redox Biol (2020) 32:101483

Monitoring reactions of nitric oxide with peptides and proteins by electrospray ionization-mass spectrometry