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Vargas KG, Milic J, Zaciragic A, et al

10.1038/s41551-023-01093-3

Immunopharmacology and Immunotoxicology, 45 , 123132

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Of the intranasally challenged mice, 20% developed meningitis without bacteremia, and the authors found that the infection induced a decreased expression and a relocation of the junction protein N-cadherin in the olfactory epithelium, which connects the nasopharynx with the CNS

Therefore, stronger basicity is suggested by lower pKb values, remaining consistent with the inverse relationship noted above