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IGF-I, IGFBP-3 and breast cancer risk in women: the european prospective investigation into cancer and nutrition (EPIC)

In research models it acts as an agonist at the ghrelin receptor (GHS-R1a) expressed on pituitary somatotrophs, promoting the release of endogenous growth hormone

And the reason comes down to one receptor that neither semaglutide nor tirzepatide activates: the glucagon receptor

The human IGF-1 literature primarily involves mecasermin (native recombinant IGF-1, brand Increlex), approved for growth failure in children with severe IGF-1 deficiency