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IgG4-sclerosing cholangitis causes a clinical picture very similar to PSC, which is characterised by elevated IgG4 levels and there may be other features of IgG4-related disease (e.g

GHK-Cu has a strong affinity for copper ions (Cu2+), which are critical cofactors for several enzymes involved in tissue repair

doi: 10.1042/bj2100289

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This approach could reveal new opportunities for using multitarget inhibitors effectively

Figure 6a: GHK and GHK-PEG did not induce cytotoxicity in SH-SY5Y cells