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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study

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5.2.2 Organic Se compounds Organic selenium compounds have attracted a lot of attention in the field of cancer research, mainly because they are usually more bioavailable and less toxic compared to inorganic selenium compounds (217)

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The enzyme methylene-tetrahydrofolate reducate (MTHFR), then converts the 5,10-methylene group to 5-methyl-THFwhich it transports of the folate cycle into the methylation cycle, in this way a single folate molecule can be recycled over 1000 times into and out of the folate cycle providing the many 5MTHF groups for regeneration of MethylCo(III)B12

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