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Nature 500 , 422426 (2013)

95% CI, 0.614 to 0.325), consistent with the findings from the period effect analysis (Figures 7A,B)

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Noisy splicing driving mRNA isoform diversity in human cells may play a similar role [48]

Interestingly, in a mouse model of coronary atherosclerosis, hemodynamic stress was shown to induce changes in sphingolipid metabolism that favored the production of S1P over ceramides, suggesting that blood vessels may be adaptative to stress [112]