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This represents a general timeline based on clinical literature

Excess ROS can oxidize biological components, leading to tissue damage (237)

80 Iron deficiency also can blunt the response to ESAs

Biochim Biophys Acta 1830, 31393142 (2013)

Eur J Cancer 42(15):26232630 Paolicchi A, Lorenzini E, Perego P, Supino R, Zunino F, Comporti M, Pompella A (2002) Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: implications for cell response to platinum-based drugs