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To analyze the flexibility of the protein residues, the root mean square fluctuation (RMSF) was measured and plotted (Fig

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Circulating syn and proinflammatory mediators are thought to compromise bloodbrain barrier (BBB) integrity and gain access to the CNS, suggesting the role of the erythrocytebrain axis in the peripheraltocentral propagation of pathology [28, 29, 30, 31]