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Sufficient daily cobalt intake is estimated to be between 0.1ppm and 0.3ppm

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Researchers should note that clinical studies on Fragment 176-191 to date have not involved administration via subcutaneous injection, but have employed infusion instead, as four escalating single doses of 25mcg 400mcg/kg, with a washout week between each administration [1]

And how would I know they'd changed it, if I couldn't see what they were doing, for example

Note that these are side effects that healthy people may experience when taking large doses of these vitamins

In addition, Fosamax is approved to treat Pagets disease of the bone