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Researchers recruited 231 healthy adults with no dementia or mild cognitive impairment through the Brain Aging Network for Cognitive Health, average age 71, median B12 concentration around 414.8 pmol/L, comfortably inside the normal range

37,38 Sympathetic signaling activates the hypothalamic-pituitary-adrenal (HPA) axis, a network that connects the nervous system to the adrenal glands and controls their release of the bodys primary stress hormone, cortisol

The deficiency of vitamin B 12 can arise from its lack in ones diet or a defect in gastrointestinal absorption [76]