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IL-13 may directly regulate melanogenesis through the JAK2-STAT6 signaling pathway (Han et al., 2014)

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Asterisks (*) notes a cyclic peptide with a different MS/MS spectrum than desmethyl-selanine B

Of particular note is the presence of the protein HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1) in the network, a key RNA-binding protein that regulates the alternative splicing of PKM pre-mRNA, thereby favoring the formation of PKM2 mRNA over that of PKM1 41,42

The first is through cross-linking with long-lived proteins, which destroys the protein structure, deforms fibres, and ultimately causes the protein to lose its biological function