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Lipid peroxidation refers to the process in which an oxygen or hydrogen peroxide molecule produces a hydroperoxy group, which is then inserted into a lipid molecule (Yang et al., 2016), which can destroy the lipid bilayer and impair membrane function ( Antioxidant System in Ferroptosis Glutathione Metabolism and System X C C Cystine/glutamate-related amino acid metabolism is crucial in ferroptosis (Yang et al., 2014)

HSP shows a high degree of homology among species from microbes to humans (Khandia et al., 2017)

CJC-1295 (no DAC) and CJC-1295 (DAC) are growth-hormone-releasing-hormone analogues, as is sermorelin

The cumulative fractional labeling from palmitate and glucose in DKO cell histone acetylation matches that by WT and ACSS2 KO cells, while ACLY KO cells have much lower cumulative labeling from these two sources, consistent with unlabeled acetate feeding the acetyl-CoA pool only in those cells (Supplemental Figure 5D)

HGH (human growth hormone) is a synthetic version that directly elevates GH levels and can have broader systemic effects (3)

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