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Key points Graves disease is an autoimmune condition that can involve the thyroid exclusively or can be associated with extrathyroidal manifestations, of which Graves orbitopathy is the most common

Synergistic action of microbiota modulation and metabolic surgery The significant improvement of NAFLD by metabolic surgery (such as sleeve gastrectomy) is partly attributed to its remodeling of the gut microbiota, providing a theoretical basis for combined microbial intervention in the perioperative period

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Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2by miR-96-5p

1 Platinum complexes which entered clinical trials While most of the platinum drugs have to be administered intravenously, Satraplatin (8) was the first orally applicable platinum agent under clinical investigation (Fig

All reagents, including the compound and minus the start reagent, were mixed and aliquoted at room temperature, followed by a 15-min incubation at 37 C