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Importance of cellular redox, mitochondrial health, and disease impact

Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation

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Given asthmas immunological complexity and heterogeneous inflammatory endotypes, further mechanistic and long-term studies including randomized clinical trials are warranted to clarify the role of GLP-1RAs in asthma management