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Collectively, theyre known as the Virchow triad: a change in blood flow, a blood vessel injury, or a change in the composition of the blood

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Because the mechanisms don't overlap, some patients use them together as parts of one supervised plan

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Administer when there are sudden changes in temperature, food or environment

Although subgroup analyses were performed, these are exploratory and may be underpowered, and residual confounding cannot be excluded MRI assessment relied on semi-quantitative MOAKS scoring rather than volumetric BML measurement, which may limit sensitivity to subtle structural changes