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doi: 10.1016/s0015-0282(01)03229-0 47 RaiganiMYaghmaeiBAmirjanntiNLakpourNAkhondiMMZeraatiHet al

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IGF-1 is the primary mediator of the effects of Growth Hormone (GH) and is responsible for most of the body's growth, anabolic (tissue-building), and recovery processes

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Moreover, the interaction of -SNAP through this hydrophobic loop is critical for its canonical and non-canonical functions as mutations in this loop reduce by ~25 times the efficiency to disassemble SNAREs complexes 11 and negatively regulate SOCE 6