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Safety: Its important to note that while AOD-9604 demonstrated excellent safety and tolerability, the clinical development program was ultimately discontinued because efficacy for weight loss did not meet regulatory approval standards

For instance, CD38 regulates the activity of the nuclear and mitochondrial SIRTUINs [6, 34-35]

Because the body cannot make B12 on its own, it has to come from food (meat, fish, eggs, dairy) or from supplements

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More research in humans is needed