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Their expertise and patience have been instrumental in helping me complete this work.I would also grateful to the staff of the Centre for Translational Medicine, Gansu Hospital, Affiliated Cancer Hospital, Sun Yat-sen University for their academic support and provision of the necessary resources for the conduct of this study.Lastly, I sincerely appreciate the valuable comments and constructive suggestions provided by the editors and anonymous reviewers

According to Bianchi-Smiraglia & Nikiforov [21], pixel-by-pixel ratiometric images were created to analyze GTP distribution within cells and one brightness setting of + 30% was used for all figure images

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