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Once opened (punctured with a needle), refrigerate at 28C and use within 28 days the benzyl alcohol preservative prevents bacterial growth for 28 days after puncture, but efficacy declines after that

Self-administered intra-articular injection risks septic arthritis (joint infection), which requires emergency IV antibiotics and possible surgical drainage within 24-48 hours of onset

Patients show significantly lower tryptophan levels in serum and feces, with an increased kynurenine/tryptophan ratio indicating enhanced IDO1 activity (203206)

A., Sun, F

Senapati DK, Yarava JR, Ramanathan K, Raghothama S

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