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The (+) strand standard was quantified by spectroscopy and diluted to indicated concentrations

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In previous years, ferroptosis has been shown to serve a key role in numerous pathological processes, including neurodegenerative diseases, cancer and inflammation-related disorders (3)

When abundantly incorporated into membrane phospholipids, PUFAs greatly increase cellular susceptibility to ferroptosis due to their high autoxidation potential ( 3.1.2 Expression and regulation of key enzymes Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are key enzymes that modulate phospholipid synthesis and remodeling

60,61,62 RNase H-dependent ASOs, such as gapmers, bind to complementary mRNA, recruit RNase H to cleave mRNA, and thus block translation of the target gene

Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial