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Moreover, the ENS produces more than 30 neurotransmitters, and the hormones and peptides it releases into circulation can cross the blood-brain barrier (BBB) and synergistically act with the vagus nerve (159)

Namely, NO-inhibition (LNAME-induced retinal ischemia) [13] and NO-over-stimulation (overproduction of NO interacting with oxygen radicals induced the death of retinal neurons) [198,199,200] may be both harmful

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10.1016/j.chom.2023.01.001 489 XiongR.-G.LiJ.ChengJ.ZhouD.-D.WuS.-X.HuangS.-Y.et al