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The concentration of 17 sICPs, including soluble form of B- and T- lymphocyte attenuator (sBTLA), sCD27, sCD28, T-cell immunoglobulin mucin-3 (sTIM-3), herpes virus entry mediator (sHVEM), sCD40, glucocorticoid-induced tumor necrosis factor receptor-related protein (sGITR), GITR ligand (sGITRL), lymphocyte-activation gene 3 (sLAG-3), sTLR-2, sPD-1, sCTLA-4, sCD80, sCD86, sPD-L1, sPD-L2, and inducible T-cell co-stimulator (sICOS) were measured using multiplexed fluorescent bead-based immunoassays with the Milliplex Map Kit (EMD Millipore Corporation, Burlington, MA, USA)

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Vohra et al., 2019)

Hepatocytes treated with 111 M for 4 hours experience an approximate 20% decrease in both cytoplasmic and mitochondrial GSH 39

The net effect of these changes on mucosal barrier properties and disease outcome can thus be expected to be the net balance of their pro- and anti-inflammatory effects