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10.1038/nri3423 109

The cagrilintide component does not add additional titration complexity because both compounds reach their maintenance doses on the same timeline

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In fact, this work was based on previous data confirming the presence of IGF-I receptors in brain capillary endothelial cells (which constitute the BBB), and their role in internalizing IGFs to the CNS from the circulation[65, 66]